Tom and Jerry Meet Child's Play is an upcoming American direct-to-video horror film, produced by Warner Bros. Pictures (WarnerMedia Byline), Warner Bros. Family Entertainment, Warner Animation Group, Warner Bros. Animation, New Line Cinema, Universal Pictures, United Artists, Metro-Goldwyn-Mayer Pictures, Hanna Barbera, HIT Entertainment, Mattel Creations and WWE Studios and slasher animated film based on the films, Child‘s Play (1988), Child’s Play 2 (1990), and Child‘s Play 3: Look Who’s Stalking (1991).
- Tom Cat - A grayish-blue cat, who is Jerry's rival and Tuffy's friend and a good friend Mrs. Mouse. In this movie, he is Andy's pet cat along together with Jerry and Tuffy to help Andy defeat Chucky.
- Jerry Mouse - A brown-orange mouse, who is Tuffy's uncle, Mrs. Mouse's son and Tom's rival. In this movie, he is Andy's pet mouse along together with Tom and Tuffy to help Andy defeat Chucky.
- Tuffy Mouse - A young baby light-grey, white diaper-wearing mouse, who is Jerry's nephew and son, Mrs. Mouse's grandson and Tom's friend. In this movie, he is Andy's pet mouse along together with Tom and Jerry to help Andy defeat Chucky and Tuffy get scare by Chucky with a knife.
- Andy Barclay - A 6-year-old boy, who is Tom, Jerry and Tuffy's owner and friend and is framed for Chucky's crimes.
- Charles Lee Ray / Voice of Chucky - A well known voodoo serial killer who transfers his soul into a "Good Guy Doll" in order to cheat death after being killed by Mike Norris and he's trying to kill Andy and his three pets named Tom, Jerry and Tuffy.
- Karen Barclay - Andy's Mother.
- Mrs. Mouse - A pink shirt, white hair and back glasses, who is Jerry's mother, Tuffy's grandmother and Tom's friend. In this movie, she is Karen's pet female mouse to rescue her son, grandson and friend away from Chucky.
- Detective Mike Norris - A senior homicide police detective and Chucky's arch-enemy.
- Maggie Peterson - Karen and Mrs. Mouse's friend and Andy's babysitter.
- Jack Santos - Norris's partner.
- Dr. Ardmore - The head doctor of a mental hospital.
- John "Dr. Death" Bishop - Chucky's former voodoo mentor.
- Eddie Caputo - Chucky's old Accomplice.
- Mr. Walter Criswell - Karen, Mrs. Mouse and Maggie's boss.
- The Orderly -
- The Peddler -
- Richard Kind as Tom Cat
- Stephanie Nadolny as Jerry Mouse
- Kath Soucie as Tuffy Mouse
- Alex Vincent as Andy Barclay
- Brad Dourif as Charles Lee Ray/Voice of Chucky
- Brock Winkless performed the puppetry of Chucky
- Catherine Hicks as Karen Barclay
- Tress MacNeille as Mrs. Mouse
- Chris Sarandon as Detective Mike Norris
- Dinah Manoff as Maggie Peterson
- Tommy Swerdlow as Jack Santos
- Jack Colvin as Dr. Ardmore
- Raymond Oliver as John "Dr. Death" Bishop
- Neil Giuntoli as Eddie Caputo
- Alan Wilder as Mr. Walter Criswell
- Aaron Osborne as the Orderly
- Juan Ramirez as the Peddler
- Rated PG (Parental Guidance) with mild bad language, violence, horror, injury detail.
- Suggested Running Times: 94 Minutes (NTSC), 91 Minutes (PAL).
- In this movie; Mrs. Mouse rescue her son Jerry and his nephew Tuffy and the friend of Tom away from Chucky with the knife.