Tom and Jerry Uncle Pecos Returns Remake to 2019 will Be Directed By Spike Brandit
- Tom Cat - A grayish-blue cat, who is Jerry's rival, Tuffy's friend, Uncle Harry, Muscles and Pecos' boss and friend.
- Jerry Mouse - A brown-orange mouse, who is Tuffy's uncle, Tom's rival, Muscles' cousin, Uncle Harry and Pecos' grandnephew.
- Uncle Pecos - A guitar-playing cowboy mouse, who is Jerry and Tuffy's uncle, Aunt Spinner's husband, Uncle Harry and Muscles' older brother and Tom's boss and friend.
- Tuffy Mouse - A young baby light-grey, white diaper-wearing mouse, who is Jerry's nephew, Tom's friend, Muscles' cousin, Uncle Harry and Pecos' grandnephew.
- Uncle Harry - A vacationing brown mouse who wears a red Hawaiian shirt with yellow flower patterns, who is Jerry and Tuffy's uncle, Tom's boss and friend, Muscles, Aunt Spinner and Uncle Pecos' older brother.
- Muscles Mouse - A super-strong mouse with yellow shirt and green bolder hat, who is Jerry and Tuffy's cousin, Uncle Harry, Aunt Spinner and Pecos' older brother, Tom's boss and friend.
- Aunt Spinner -
- Cowboy Mouse -
- Cowgirl Sister -
- Cowboys Mom -
- Cowboy Brother -
- Officer John -
- Pizza Man -
- Don Brown as Tom
- Samuel Vincent as Jerry
- Scott McNelie as Uncle Pecos
- Tara Strong as Tuffy
- John Michael Higgins as Uncle Harry
- Maurice LaMarche as Muscles
- Ellen Kennedy as Aunt Spinner
- Max Charles as Cowboy Mouse
- Neve Campbell as Cowgirl Sister
- Emily Blunt as Cowboys Mom
- Nicky Jones as Cowboy Brother
- Jack Angel as Officer John
- Carlos Alazraqui as Pizza Man
- Rated G (General Audience) with mild violence, threat, language.
- Suggested Running Times: 99 Minutes (NTSC), 95 Minutes (PAL).
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