Tom and Jerry: Madagascar is an upcoming American direct-to-video computer-animated comedy film, produced by Warner Bros. Pictures (WarnerMedia Byline), Warner Bros. Animation, Universal Pictures, DreamWorks Animation and Metro-Goldwyn-Mayer Pictures based on (Madagascar 2005).
From the Studio That Brought You: Shrek, Shark Tale, Madagascar, Tom and Jerry: Robin Hood and his Merry Mouse, Tom and Jerry & The Wizard of Oz, Tom and Jerry: Back to Oz, Tom and Jerry: The Lost Dragon, Tom and Jerry: Spy Quest and Tom and Jerry: Willy Wonka and the Chocolate Factory.
- Tom Cat - A grayish-blue cat, who is Jerry's rival and Tuffy's friend. In this movie, he helps with Alex, Marty, Melman and Gloria along together with Jerry and Tuffy and their friends.
- Jerry Mouse - A brown-orange mouse, who is Tuffy's uncle and Tom and Quacker's friend. In this movie, he helps with Alex, Marty, Melman and Gloria along together with Tom and Tuffy and their friends.
- Tuffy Mouse - A young baby light-grey, diaper-wearing mouse, who is Jerry's nephew, Tom and Quacker's friend. In this movie, he helps with Alex, Marty, Melman and Gloria along together with Tom, Jerry and Quacker.
- Quacker - A little yellow duckling, who is Jerry's little buddy, Tom and Tuffy's friend. In this movie, he helps with Alex, Marty, Melman and Gloria along together with Jerry, Tom and Tuffy.
- Alex - A lion.
- Marty - A plains zebra.
- Melman - A hypochondriac reticulated giraffe who is afraid of germs.
- Gloria - A strong, confident, but sweet hippopotamus.
- King Julien XIII - A ring-tailed lemur and the king of the lemurs.
- Maurice - An aye-aye and King Julien's royal advisor.
- Mort - A Goodman's mouse lemur.
- Skipper - The leader of penguins.
- Kowalski - A penguin and Skipper's right hand.
- Timo - A tenrec who is only seen attending Julien's meeting.
- Rico - A smart and silent penguin who is only expressed through grunts and squeals.
- Abner - A blue-eyed lemur who is only seen at the paradise scene.
- Private - An eager, lowly penguin.
- Mason - A chimpanzee.
- Ted - A Golden Bamboo lemur.
- The Fossa -
- Hector and Horst - Two lemurs.
- Pancho - A crowned lemur.
- Becca - A black lemur.
- Nana - An elderly New Yorker.
- An unspecified off-screen zoo animal -
- A police horse -
- A police officer -
- Richard Kind as Tom Cat
- Stephanie Nadolny as Jerry Mouse
- Kath Soucie as Tuffy Mouse
- Sam Kwasman as Quacker
- Ben Stiller as Alex the Lion
- Chris Rock as Marty the Zebra
- David Schwimmer as Melman the Giraffe
- Jada Pinkett Smith as Gloria the Hippopotamus
- Tom McGrath as Skipper
- Jeff Bennett as Kowalski
- John DiMaggio as Rico
- Christopher Knights as Private
- Danny Jacobs as King Julien
- Kevin Michael Richardson as Maurice
- Andy Richter as Mort
- Rated G (General Audience).
- Suggested Running Times: 90 Minutes (NTSC), 86 Minutes (PAL).
- Tom and Jerry wears their swim trunks as they did in Tom and Jerry: Spy Quest.
- Tom and Jerry wear their swim trunks through the whole movie.
- Tom wears a red swim trunks for swimming.
- Jerry wears a blue swim trunks and see his brown-buttocks and tail for swimming.
- Jerry wears blue swim trunks and see his brown-buttocks and tail under his blue swim trunks in this movie, rather than his yellow swim trunks.
- Tuffy wears a white inflatable waterproof diaper for swimming and see his light-grey buttocks under his inflatable waterproof diaper and tail for swimming.
- Tuffy's white inflatable waterproof diaper has a trigger that activates the diaper to inflate some air to keep Tuffy floating in the water.
- Quacker wears a green swim trunks for swimming.
- In this movie, See Gloria and her huge grey buttocks.