Scooby-Doo! Meets 101 Dalmatians is an upcoming direct-to-DVD computer-animated comedy film produced by Warner Bros. Animation, Hanna-Barbera and Walt Disney Pictures.
- Fred Jones
- Shaggy Rogers
- Velma Dinkley
- Daphne Blake
- Pongo - The father of the Dalmatians puppies.
- Perdita - The mother of the Dalmatians puppies and the wife of Pongo.
- Lucky - The most plucky of the puppies and is unique in having his only spots in the shape of a horseshoe on his back.
- Cadpig - The smallest of the Dalmatian puppies.
- Rolly - The very hungry Dalmatian.
- Spot - A female chicken who wants to become a Dalmatian.
- Frank Welker as Scooby-Doo, Fred Jones
- Matthew Lillard as Shaggy Rogers
- Kate Micucci as Velma Dinkley
- Grey Griffin as Daphne Blake
- Samuel West as Pongo
- Kath Soucie as Perdita, Cadpig, Rolly
- E. G. Daily as Lucky
- Tara Strong as Spot the Chicken
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