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It is a remake of the 2016 CGI-animated film of the same name.
- Danny McBride as Manny, as Manny, the woolly mammoth.
- Billy Crystal as Sid, the giant ground sloth.
- Harrison Ford as Diego, the smilodon.
- Tiffany Haddish as Ellie, a Woolly Mammoth, and Manny's wife.
- Keke Palmer as Peaches, a teenage Woolly Mammoth and Manny and Ellie's daughter.
- Drake Bell as Julian, a male woolly mammoth and Peaches' husband.
- Sean William Scott as Crash
- Josh Peck as Eddie
- Wanda Sykes as Granny
- Emily Blunt as Shira
- Simon Pegg as Buck
- Nick Offerman as Gavin
- Bill Hader as Roger
- Anna Paquin as Gertie
- Lucy Liu as Brooke
- Jesse Tyler Ferguson as Shangri Llama
- Chris Wedge as Scrat, the saber-toothed squirrel.
- Matt Damon as The Narrator
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