Osmosis Jones (2001)

Osmosis Jones is a 2001 American live-action/animated action comedy film with animated scenes directed by the Farrelly brothers. The film centers on Frank Detorre, a slovenly zookeeper; the live-action scenes are set inside his body, which is portrayed as a city inhabited by anthropomorphic blood cells and microorganisms. White blood cell cop Osmosis "Ozzy" Jones and cold pill Drix must prevent deadly virus Thrax from killing Frank forty-eight hours.

Starring by

 * Chris Rock - Osmosis "Ozzy" Jones
 * Laurence Fishburne - Thrax, main villain
 * David Hyde Pierce - Drixenol "Drix" Koldreliff
 * Brandy Norwood - Leah Estrogen
 * William Shatner - Mayor Phlegmming
 * Ron Howard - Tom Colonic